منابع مشابه
Mash1 regulates neurogenesis in the ventral telencephalon.
Previous studies have shown that mice mutant for the gene Mash1 display severe neuronal losses in the olfactory epithelium and ganglia of the autonomic nervous system, demonstrating a role for Mash1 in development of neuronal lineages in the peripheral nervous system. Here, we have begun to analyse Mash1 function in the central nervous system, focusing our studies on the ventral telencephalon w...
متن کاملOn the Mechanisms of Neural Development in the Ventral Telencephalon
To be presented for public examination with the permission of the Faculty of Para a minha família TABLE OF CONTENTS LIST OF ORIGINAL PUBLICATIONS i ABSTRACT ii LIST OF ABBREVIATIONS iv INTRODUCTION 1 1. The development of telencephalon in mouse 1 1.1. Neural development within the telencephalon 2 1.1.1. Neurogenesis and cell migration within the dorsal telencephalon 3 Use of decloaking chamber-...
متن کاملLRP2/megalin is required for patterning of the ventral telencephalon.
Megalin is a low-density lipoprotein receptor-related protein (LRP2) expressed in the neuroepithelium and the yolk sac of the early embryo. Absence of megalin expression in knockout mice results in holoprosencephaly, indicating an essential yet unidentified function in forebrain development. We used mice with complete or conditional megalin gene inactivation in the embryo to demonstrate that ex...
متن کاملFoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation.
FoxG1 is a conserved transcriptional repressor that plays a key role in the specification, proliferation and differentiation of the telencephalon, and is expressed from the earliest stages of telencephalic development through to the adult. How the interaction with co-factors might influence the multiplicity and diversity of FoxG1 function is not known. Here, we show that interaction of FoxG1 wi...
متن کاملSonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon.
Fate determination in the mammalian forebrain, where mature phenotypes are often not achieved until postnatal stages of development, has been an elusive topic of study despite its relevance to neuropsychiatric disease. In the ventral telencephalon, major subgroups of cerebral cortical interneurons originate in the medial ganglionic eminence (MGE), where the signaling molecule sonic hedgehog (Sh...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2007
ISSN: 1933-6918,1933-6926
DOI: 10.4161/cam.1.4.5546